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股票配资如何 康 · 学术 | Reaction of the Day No. 1297

当地时间周三(8月23日)，据塔斯社援引俄罗斯紧急情况部消息报道，一架私人飞机在俄罗斯特维尔州坠毁，造成10人死亡。这架从莫斯科飞往圣彼得堡的飞机上的三名飞行员和七名乘客全部遇难。据俄罗斯联邦航空运输署的报道称，瓦格纳组织创始人普里戈任被列入周三在莫斯科北部特维尔地区坠毁的一架私人飞机上的乘客名单。

转自：康龙化成

Amination of Aminopyridines via η6‑Coordination Catalysis

JiajiaChen, Yunzhi Lin, Wen-Qiang Wu, Wei-Qiang Hu, Jingkai Xu, and Hang Shi*

Key Laboratory of Precise Synthesis ofFunctional Molecules of Zhejiang Province, School of Science, WestlakeUniversity, Hangzhou 310030 Zhejiang Province, China; Institute of NaturalSciences, Westlake Institute for Advanced Study, Hangzhou 310024 ZhejiangProvince, China;

—J. Am. Chem. Soc.,2024, 146, 22906−22912

Recommended by Rui Jin _ MC5

ABSTRACT: Pyridine,a widespread aromatic heterocycle, features asp2-hybridizednitrogen atom that can readily coordinate to metals, leading to distinctiveachievements in catalysis. In stark contrast, π-coordination of pyridine andderivatives with transition metals is notably scarce, and the involvement ofsuch activation mode in catalysis remains to be developed. Herein, we presentamination reactions of aminopyridines that leverages the reversible πcoordination with a ruthenium catalyst as the arenophilic π acid, rather than relying on theconventional κ-N coordination. Specifically, atransient η6-pyridine complex functions as theelectrophile in the nucleophilic aromatic substitution with amines, providing adiverse array of products via the cleavage of the pyridyl C−N bond. Inaddition, this method can be employed to incorporate chiral amines and 15N-labeled amines.

Background and This Work

Selected Examples of Catalytic Aminationof 2-Aminopyridines and Extended Applications

（转自：康龙化成）股票配资如何

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